Skin Diseases & Skin Care

Comparative evaluation of therapeutic efficacy and safety of dermabrasion with PGE2 analogue (Dinoprostone), 5-Flourouracil cream (5%) and Tacrolimus (0.1%) cream in localised stable vitiligo

Vitiligo is associated with huge social stigma in Asain skin. The desire of novel molecules has been since long in the management of vitiligo.  Our aim in the study was to evaluate therapeutic efficacy and safety of dermabrasion with PGE2 analogue (Dinoprostone gel), 5-Flourouracil (5%) cream and Tacrolimus 0.1% cream in localised stable vitiligo

Methodology & Theoretical Orientation: 60 patients of localised stable vitiligo were taken which were randomly divided into 3 groups. Dermabrasion with Dinoprostone gel, 5-Flourouracil and Tacrolimus 0.1% ointment  was done in group 1, 2, and 3 respectively. The respective topical agents were instructed to be applied twice daily till 12 weeks. Follow up was done by VASI, DLQI and photographically four weekly till  36 weeks.

Findings: Repigmentation started within 4 weeks in all 3 groups. Excellent response (>75% repigmentation ) was seen in 43%,40% and 54% of group1,2 and 3 patients respectively. Good response(>50% respigmenatation) was observed in 34%,26%, 33%, of patients of group1,2 and 3 respectively. 25-50% repigmentation was seen in 4%,8%,10% in group1,2 and 3 patients respectively.  No significant side effects or reoccurrence  were found in the study period.

Conclusions and significance: Dermabrasion when combined with Dinoprostone gel, 5-Flourouracil (5%), or tacrolimus 0.1% ointment showed similar efficacy and side effect profile in all 3 groups with slight better response with tacrolimus ointment. This study adds novel molecule dinoprostone to the already existing basket for vitiligo management.

Author(s):

Jaskirat kaur

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