Skin Diseases & Skin Care

Neuronal Precursor Cell Expressed Developmentally down Regulated 4 (NEDD 4) gene polymorphism in keloid patients: A Clinical and Genetic study

Background: Keloids represent chronic fibroproliferative disorders of the skin which is characterized by excessive deposition of extracellular components especially collagen type 1, fibronectin and elastin.  The exact aetiology of keloid formation is undefined but its development rests on genetic and environmental factors. Aim: to investigate NEDD4 (rs8032158) gene polymorphism in a sample of Egyptian patients having keloid. Patients and methods: The current case-control study was done on 80 subjects; 50 keloid patients and 30 ages and sex matched apparently healthy controls. All subjects underwent full history, weight and length measuring to calculate BMI, dermatological examination and analysis of NEDD4 rs8032158 (T/C) gene polymorphism using Real Time-PCR. Results: rs8032158 CC genotype was significantly observed in keloid patients and increased the risk for keloid development by about 4 times (p=0.038, OR=4.20) and was significantly associated with severe form of keloid (p<0.001). Moreover, C allele significantly increased the risk for keloid development by about 2 folds (P=0.028, OR =2.08). Conclusion:  NEDD4 (rs8032158) gene polymorphism could participate in keloid formation in Egyptian population. NEDD4 (rs8032158) CC genotype may have a role in keloid severity.

Author(s):

Azza GA Farag, Wafaa Ahmed Shehata, Mostafa A Hammam, Mustafa Elsayed Elshaib, Nermin Reda Tayel, Sahar Elsoudy Ibrahim Hommos and Eman Masoud AbdElGayed

Abstract | PDF

Share this