Skin lipids, combine of, keratinocyte, sebocyte, and microbe- derived lipids, intensely effect to the skin status by various mechanisms. Those are Physical chemistry function, Biochemistry function, and Micro ecology function. Lipids are vital metabolites that ensure many essential cellular functions, including energy metabolism,
enzyme activation, signal transduction, cell proliferation,
transmembrane transport, differentiation and apoptosis. They are separated into classes and subclasses based on the head group and the type of linkage among the aliphatic chains and head groups. Classification system providing by lipid metabolites and pathways strategy is a web portal intended to be a entry to lipid omics resource. Those subclasses are Glycolipids (GL), fatty acids (FA), sphingolipids (SP), saccharolipids (SL), prenol lipids (PR), sterol lipids (ST), glycerophospholipids (GP), and polyketides (PK).Lipids possibly will be defined as amphipathic or hydrophobic small molecules those originate completely or in part through carbanion-based compressions of thioesters or by carbocation based compressions of isoprene units.