Skin Diseases & Skin Care

Clinical performance of Repavar® rosehip oil formulation enriched with growth factors in the treatment of cutaneous lesions: A prospective multicenter study under routine

Objective: To evaluate the clinical efficacy and tolerability of a topical rosehip oil formulation enriched with growth factors in the treatment of different types of cutaneous lesions under routine clinical conditions. Objective to evaluate the clinical efficacy and tolerability of a topical rosehip oil formulation enriched with growth factors in the treatment of different types of cutaneous lesions under routine clinical conditions. Methods: A prospective, multicenter, open-label clinical study was conducted in 24 dermatology centers in Spain. A total of 105 adult participants with cutaneous lesions were enrolled, of whom 97 completed the study. Participants were classified into three groups: scars [n=53], ulcers [n=15] and post-dermatological procedure lesions [n=29]. The study product was applied twice daily for 1â??3 months depending on the lesion type. Clinical assessments were performed using modified POSAS and PUSH scales and a specific inflammatory lesion scale. Patients also completed evaluations using the POSAS scale, subjective questionnaires and satisfaction questionnaires for both panelists and researchers. Photographs were also taken at each experimental time point. Statistical analyses were conducted using cumulative mixed effects linear models, generalized linear mixed-effects models and McNemarâ??s test, selected according to the distribution and structure of each outcome variable. Results: Clinically meaningful and progressive improvements were observed across all lesion types. In the scar group, vascularization decreased by up to 70%, pigmentation by 67% and scar thickness by up to 75% after 12 weeks. Overall scar appearance improved by up to 59%. In patients with ulcers, lesion area decreased by 50%, with reductions in exudate and improvements in tissue characteristics. In post-procedural lesions, erythema, edema and epidermal barrier disruption improved rapidly, with overall lesion recovery reaching 85% after four weeks. Conclusions: The topical formulation containing rosehip oil and growth factors demonstrated clinically significant improvements in the healing of different types of cutaneous lesions and may represent a useful option for enhancing skin regeneration in dermatological practice.

Author(s): Lorena Bellas, Lourdes Ubiria, V�­ctor Mic�³, Husein Husein-ElAhmed, Francisco Benavente Ortiz, Lisset M. Sard�¡, Sara B. Alvarez, Amaia de Mariscal, Inmaculada Garay, Fernando Pulgar, Antonio Morillo-Velarde, Miguel Servera, Anna L�³pez, Gala Valero, Marion M. Chavez-Bourgeois, Juan M. Revelles, Elena Sotomayor, Carmen Carranza, Sara I. Palencia, Nuria Diez, Josep Gonz�¡lez, Priti M. Melwani, Mar�­a T. Arguisjuela, Nuria P�©rez, Francisco M. Almaz�¡n-Fern�¡ndez, Santiago Vidal-Asensi

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